May 1, 2018 – Systems Biology for Target and Drug Discovery, Dr. Hsueh-Fen Juan

Speaker: Dr. Hsueh-Fen Juan, Professor, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Editor Board of Scientific Reports (Nature Research) Vice Chairman, Taiwan Bioinformatics and Systems Biology Society

Date/Time: Tuesday, May 1, 2018 from 11:00am to 12:00pm

Location: CEME 1203

Title: Systems Biology for Target and Drug Discovery

Precision medicine is a medical model with the idea that molecular information improves the precision with which patients are categorized and treated. Systems biology, one of the applications of precision medicine, aims to analyze the molecular expression level of an individual patient and further for targeted therapy. In this talk, I will represent how to find out drug targets and drugs in lung and breast cancers as well as neuroblastoma using systems biology approach. Here, we integrated not only proteome but also various gene expression datasets to identify potential drug targets. A natural language processing method, Platform-Independent Latent Dirichlet Allocation (PLIDA), was used for reducing cross-platform effect. We further analyzed one billion data of Library of Integrated Network-based Cellular Signatures (LINCS), a project by National Institute of Health (NIH), which comprised tens of thousands of perturbing agents in multiple cell lines. From the analysis results, we found several key genes and drugs with the potential for cancer therapy. We demonstrated the candidate drugs suppressed cancer cell proliferation in cell model and reduced tumor size and increased survival in mouse model. In summary, we identified the promising drugs that may recurrently target these pivotal genes for precision medicine.