Seminar: Patient-specific modeling for virtual treatment planning in cardiovascular disease
Speaker: Dr. Alison Marsden
Wall Center scholar in the departments of Pediatrics, Bioengineering, and, by courtesy, Mechanical Engineering, Stanford University
Zoom Link: https://ubc.zoom.us/j/67259064665?pwd=SklOeFFSS1Z3TkhWYWIzK1lxcTVxdz09
Meeting ID: 672 5906 4665 | Passcode: 257541
Cardiovascular disease is the leading cause of death worldwide, with nearly 1 in 4 deaths caused by heart disease alone. In children, congenital heart disease affects 1 in 100 infants, and is the leading cause of infant mortality in the US. Patient-specific modeling based on medical image data increasingly enables personalized medicine and individualized treatment planning in cardiovascular disease patients, providing key links between the mechanical environment and subsequent disease progression. We will discuss recent methodological advances in cardiovascular simulations, including (1) uncertainty quantification to assess reliability of simulation predictions, and (2) a unified finite element formulation for fluid structure interaction and fluid solid growth simulations. Clinical application of these methods will be demonstrated in two clinical applications: 1) virtual treatment planning in pediatric patients with peripheral pulmonary stenosis, and 2) prevention of vein graft failure after coronary bypass graft surgery. We will briefly discuss our open source SimVascular project, which is available to the scientific community (www.simvascular.org). Finally, we will provide an outlook on recent successes and challenges of translating personalized simulation tools to the clinic.
Alison Marsden is a Professor in the departments of Pediatrics, Bioengineering, and, by courtesy, Mechanical Engineering at Stanford University. She is a member of the Institute for Mathematical and Computational Engineering. From 2007-2015 she was a faculty member in Mechanical and Aerospace Engineering at UCSD. She graduated with a BSE degree in Mechanical Engineering from Princeton University in 1998, and a PhD in Mechanical Engineering from Stanford in 2005. She was a postdoctoral fellow at Stanford University in Bioengineering from 2005-07. She was the recipient of a Burroughs Wellcome Fund Career Award at the Scientific Interface in 2007, an NSF CAREER award in 2011. She was elected fellow of AIMBE and SIAM in 2018, the APS DFD in 2020, and BMES in 2021. Her research focuses on the development of numerical methods for cardiovascular blood flow simulation and application of engineering tools to impact patient care in cardiovascular surgery and congenital heart disease.