Hongshen Ma

Hongshen Ma

Hongshen Ma

Professor

B.A.Sc (UBC), M.Sc. (MIT Media Laboratory), Ph.D. (MIT Electrical Engineering); Associate Appointments: School of Biomedical Engineering, Pathology and Laboratory Medicine, Urologic Sciences

phone: (604) 827-4703
email: hongma@mech.ubc.ca
website:  Multi-Scale Design Laboratory
office: ICICS 167

Research Interests

My research program aims to develop new technologies to interrogate and manipulate biological systems at the scale of individual cells. Our work leverages advances in materials, fabrication, instrumentation, and computation across multiple domains and length scales. Current research activities include the following areas:

  • Microfluidics
  • Cell Sorting
  • Cell Biomechanics
  • Single cell sequencing
  • Single cell secretion
  • Image cytometry
  • Machine Learning
  • Laboratory automation

Selected Publications

  • Lee JH, Park ES, Choi JR, Matthews K, Lam AV, Deng X, Duffy SP, Ma H, See-N-Seq: RNA Sequencing of Target Single Cells Identified by Microscopy via Micropatterning of Hydrogel Porosity. Communications Biology, 5, 768, 2022 [Link to article]
  • Lamoureux ES, Islamzada E, Wiens MVJ, Matthews K, Duffy SP, Ma H, Assessing Red Blood Cell Deformability using Deep Learning. Lab on a Chip, 22, 26-39, 2022. [Link to article; BioRxiv]
  • Lee R, Witherspoon L, Robinson M, Lee JH, Duffy SP, Flannigan R, Ma H, Deep Learning-based Automated Rare Sperm Identification from Testes Biopsies. Fertility and Sterility, 118, 90-99, 2022. [Link to article; BioRxiv]
  • Islamzada E, Lamoureux ES, Matthews K, Duffy SP, Mark D. Scott, Ma H, Blood Unit Segments Accurately Represent the Biophysical Properties of Red Blood Cells in Blood Bags but Not Hemolysis. Transfusion, 62, 448-456, 2022. [Link to article; BioRxiv]
  • Choi JR, Lee JH, Xu A, Matthews K, Xie S, Duffy SP, Ma H, Monolithic Hydrogel Nanowells-in-Microwells Enabling Simultaneous Single Cell Secretion and Phenotype Analysis, Lab on a Chip, 2020. (Accepted) [Link to article]
  • Berryman S, Matthews K, Lee JH, Duffy SP, Ma H, Image-based Cell Phenotyping Using Deep Learning, Communications Biology, 3, 674, 2020. [Link to article]
  • Chiu JCY, Teodoro J, Lee JH, Matthews K, Duffy SP, Ma H, Selective Laser Gelation of Methylcellulose Enabling Selective Propagation of Antibody-Producing Cells, Lab on a Chip, 20, 1544-1553, 2020. [Link to article]
  • Lee JH, Santoso AT, Park ES, Matthews K, Duffy SP, Ma H, Lossless Immunocytochemistry using Photo-polymerized Hydrogel Thin-films, Analyst, 145, 2897-2903, 2020. [Link to article]
  • Islamzada E, Matthews K, Guo Q, Duffy SP, Ma H, Deformability based Sorting of Stored Red Blood Cells Reveals Donor-dependent Aging Curves, Lab on a Chip, 20, 226-235, 2020. [Link to article; Article profiles: AABB News, CityTV, EurekAlert, IFL Science, Bioengineer.org, Science Codex, UBC News]
  • Park ES, Yan JP, Ang RR, Lee JH, Deng X, Duffy SP, Beja K, Annala M, Black PC, Chi KN, Wyatt AW, Ma H, Isolation and Genome Sequencing of Individual Circulating Tumor Cells using Hydrogel Encapsulation and Laser Capture Microdissection, Lab on a Chip, 18(12), 1736-1749, 2018. [Link to article]
  • Guo Q, Duffy SP, Matthews K, Deng X, Santoso AT, Islamzada E, Ma H, Deformability based Sorting of Red Blood Cells Improves Diagnostic Sensitivity for Malaria Caused by Plasmodium Falciparum, Lab on a Chip (Communication), 16, 645-654, 2016. [Link to article]
  • Park ES, Jin C, Guo Q, Ang RR, Duffy SP, Matthews K, Azad A, Abdi H, Todenhöfer T, Bazov J, Chi KN. Continuous flow deformability‐based separation of circulating tumor cells using microfluidic ratchets. Small, 12(14), 1909-1919, 2016. [Link to article]
  • Deng X, Duffy SP, Myrand-Lapierre M, Matthews K, Santoso AT, Du Y, Ryan KS, Ma H, Reduced Deformability of Parasitized Red Blood Cells as a Biomarker for Antimalarial Drug Efficacy, Malaria Journal, 14(1), 428, 2015. [Link to article]
  • Myrand-Lapierre M, Ang RR, Deng X, Matthews K, Santoso AT, Ma H, Multiplexed Fluidic Plunger Mechanism for High-Throughput Analysis of Red Blood Cell Deformability, Lab on a Chip, 15(1), 159-167, 2015. [Link to article]
  • Jiménez-Díaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O’Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gómez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martínez MS, Miller G, Rodríguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK, (+)-SJ733: A Clinical Candidate for Malaria that Acts Through ATP4 to Induce Rapid Host-Mediated Clearance of Plasmodium, Proceedings of the National Academy of Sciences of the United States of America, 111(50), E5455-62, 2014. DOI:10.1073/pnas.1414221111. [Link to article]
  • Park S, Ang RR, Bazov J, Chi KN, Black PC, Ma H, Morphological Differences Between Circulating Tumour Cells from Prostate Cancer Patients and Cultured Prostate Cancer Cells, PLOS ONE, 9(1), e85264, 2014. [Link to article]

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