Lyndia Wu

Assistant Professor

B.A.Sc. (Toronto); M.S. (Stanford); Ph.D. (Stanford); Postdoctoral Fellowship (Stanford)

Research Interests

• Injury Biomechanics
• Soft Tissue Biomechanics
• Traumatic Brain Injury
• Sleep Biomechanics
• Sensors and Instrumentation
• Data Mining and Machine Learning

Current Research Work

The general goal of the lab is to develop novel sensing and data analytics to study the biomechanics of the human body in health and disease states. One main research area is brain injury or concussion biomechanics, where we employ sensing, modeling, and machine learning tools to study the mechanism of traumatic brain injury. Other areas include the development of novel sensors and algorithms to study sleep disorders such as obstructive sleep apnea.

Selected Publications

• Gabler, L., Patton, D., Begonia, M., Daniel, R., Rezaei, A., Huber, C., Siegmund, G., Rooks, T., Wu, L.C. Consensus Head Acceleration Measurement Practices (CHAMP) – Laboratory Validation of Wearable Sensor Systems. Annals of Biomedical Engineering. Online. 1-16. (2022)
• Rezaei, A., Wu, L.C. Automated soccer head impact exposure tracking using video and deep learning. Scientific Reports. 12(1): 1-12. (2022).
• Kenny, R., Elez, M., Clansey, A., Virji-Babul, N., and Wu, L.C., Head Impact Exposure and Biomechanics in University Varsity Women’s Soccer. Annals of biomedical engineering, Online. (2022).
• Wang, T., Kenny, R. and Wu, L.C., Head impact sensor triggering bias introduced by linear acceleration thresholding. Annals of biomedical engineering, 49(12): 3189-3199. (2021).
• Qiao, C. Z., Chen, A., Blouin, J. S., and Wu, L. C. Potential mechanisms of acute standing balance deficits after concussions and subconcussive head impacts: a review. Annals of biomedical engineering, Online. 1-23. (2021).
• Domel, A.G., Raymond, S.J., Giordano, C., Liu, Y., Yousefsani, S.A., Fanton, M., Cecchi, N.J., Vovk, O., Pirozzi, I., Kight, A. Avery, B., Boumis, A., Fetters, T., Jandu, S., Mehring, W.M., Monga, S., Mouchawar, N., Rangel, I., Rice, E., Roy, P., Sami, S., Singh, H., Wu, L.C., Kuo, C., Zeineh, M., Grant, G., and Camarillo, D.B. A new open-access platform for measuring and sharing mTBI data. Scientific Reports, 11(1):1-10. (2021).
• Ozkaya, E., Fabris, G., Macruz, F., Suar, Z.M., Abderezaei, J., Su, B., Laksari, K., Wu, L.C., Camarillo, D.B., Pauly, K.B., Wintermark, M., and Kurt, M. Viscoelasticity of children and adolescent brains through MR elastography. Journal of the Mechanical Behavior of Biomedical Materials, 115(104229):1-9. (2021).
• Tierney, G.J., Kuo, C., Wu, L.C., Weaving, D. and Camarillo, D. Analysis of head acceleration events in collegiate-level American football: A combination of qualitative video analysis and in-vivo head kinematic measurement. Journal of Biomechanics, 110(109969): 1-7. (2020).
• Lv, H., Kurt, M., Zeng, N., Ozkaya, E., Marcuz, F., Wu, L.C., Laksari, K., Camarillo, D.B., Pauly, K.B., Wang, Z. and Wintermark, M., 2020. MR elastography frequency–dependent and independent parameters demonstrate accelerated decrease of brain stiffness in elder subjects. European Radiology, 30(12):6614-6623. (2020).
• Laksari, K., Fanton, M., Wu, L.C., Nguyen, T.H., Kurt, M., Giordano, C., Kelly, E., O’Keeffe, E., Wallace, E., Doherty, C., Campbell, M., Tiernan, S., Grant, G., Ruan, J., Barbat, S., Camarillo, D.B. Multi-directional dynamic model for traumatic brain injury detection. Journal of Neurotrauma. 37(7):982-993. (2020).
• Kurt, M., Wu, L.C., Laksari, K., Ozkaya, E., Suar, Z.M., Lv, H., Epperson, K., Epperson, K., Sawyer, A.M., Camarillo, D.B., Pauly, K.B., Wintermark, M. Optimization of a Multi-Frequency MR Elastography Protocol for the Human Brain. Journal of Neuroimaging. 29(4):440-446. (2019).
• Wu, L.C., Steinberg, G., Zhang, Y., Qu, H., Huang, S., Cheng, M., Bliss, T., Du, F., Rao, J., Song, G., Pisani, L., Doyle, T., Conolly, S., Krishnan, K., Grant, G., Wintermark, M. A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging. American Journal of Neuroradiology. 40(2):206-212. (2019).
• Kuo, C., Wu, L.C., Loza, J., Senif, D., Anderson, S. and Camarillo, D.B. Comparison of Video-based and Sensor-based Head Impact Exposure. Plos One. 13(6):1:19. (2018).
• Wu, L.C., Kuo, C., Loza, J., Kurt, M., Laksari, K., Yanez, L.Z., Senif, D., Anderson, S.C., Miller, L.E., Urban, J.E., Stitzel, J.D., Camarillo, D.B. Detection of American Football Head Impacts Using Biomechanical Features and Support Vector Machine Classification. Scientific Reports. 8(1):855. (2017).
• Miller, L.E., Kuo, C., Wu, L.C., Urban, J.E., Camarillo, D.B., Stitzel, J.D. Validation of a Custom Instrumented Retainer Form Factor for Measuring Linear and Angular Head Impact Kinematics. Journal of Biomechanical Engineering. 140(5):1-6. (2017).
• Kuo, C.*, Wu, L.C.*, Ye, P. P.*, Laksari, K., Camarillo, D. B., & Kuhl, E. Pilot findings of brain displacements and deformations during roller coaster rides. Journal of Neurotrauma. 34(22):3198-3205. (2017). *Equal contribution.
• Zhao, W., Kuo, C., Wu, L.C., Camarillo, D. B., & Ji, S. Performance evaluation of a pre-computed brain response atlas in dummy head impacts. Annals of biomedical engineering. 45(10):2437-2450. (2017).
• Wu, L.C., Laksari, K., Kuo, C., Kleiven, S., Luck, J.F., Bass, C.R., Camarillo, D.B., Bandwidth and Sample Rate Requirements for Wearable Head Impact Sensors. Journal of Biomechanics. 49(13):2918-2924. (2016).
• Wu, L.C., Nangia, V., Bui, K., Hammoor, B.T., Kurt, M., Hernandez, F., Kuo C., In vivo Evaluation of Wearable Head Impact Sensors. Annals of Biomedical Engineering.  44(4):1234-1245. (2015).
• Laksari, K., Wu, L.C., Kurt, M., Kuo C., Resonance of Human Brain Under Head Acceleration. Journal of the Royal Society Interface. 12(108):20150331. (2015).
• Hernandez, F., Wu, L.C., Yip, M.C., Kleiven, S., Hoffman A.R., Lopez, J., Grant, G., Camarillo, D.B. Six Degree of Freedom Measurements of Human Mild Traumatic Brain Injury. Annals of Biomedical Engineering. 43(8):1918-1934. (2015).
• Wu, L.C., Zarnescu, L., Nangia, V., Cam, B., Camarillo, D. A Head Impact Detection System Using SVM Classification and Proximity Sensing in an Instrumented Mouthguard.  IEEE Transactions on Biomedical Engineering. 61(11):2659–2668. (2014).
• Abdelgawad, M., Wu, L.C., Chien, W.Y. & Sun, Y. A Fast and Simple Method to Fabricate Circular Microchannels in Polydimethylsiloxane (PDMS). Lab on a Chip. 11(3):545-551. (2011).

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